Frédéric Frottin

Frédéric Frottin performs his studies at the Institute for Integrative Biology of the Cell (I2BC, Gif-sur-Yvette, France). Frédéric obtained his PhD in cellular biochemistry in 2011 from the University of Paris-Saclay (France). He then joined the department of Prof. F.U. Hartl at the Max Planck Institute of Biochemistry (Munich, Germany) to work on pathways relevant for neurodegenerative disorders. This is where he picked up his interest for nuclear proteostasis. Late 2020, he obtained a permanent researcher position at the I2BC to continue his research on understanding both protein quality control pathways operating in the nucleus and how aberrant nuclear proteins challenge nuclear functions. In particular, he studies the crosstalk between nuclear biocondensates and protein quality control. 

Webinar Summary:

A distinctive feature of eukaryotic cells is their high degree of compartmentalization, requiring specific and adapted proteostasis networks for each compartment. The nucleus, essential for maintaining the integrity of genetic information and gene transcription, is one such compartment. While protein quality control (PQC) mechanisms have been investigated for decades in the cytoplasm, our knowledge of nuclear PQC pathways is only emerging. Similarly, how aberrant proteins impair nuclear functions is poorly understood. Recent developments in the field have underscored the importance of spatially managing aberrant proteins within the nucleus, with the nucleolus acting as a hub for quality control. In this webinar, I will discuss these recent developments focusing on the nucleolus as protein quality control compartment and highlight C9Orf72 nuclear products as example of disease-related toxic proteins.

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